Paul Byron was born on April 27, 1989 in Ottawa, Ontario. He played his junior hockey for the Gatineau Olympiques of the Quebec Major Junior League where his offensive flare drew the attention of the Buffalo Sabres organization who selected him sixth round of the 2007 NHL Entry Draft.
Byron would spend the majority of his time in the Sabres' organization with the club's AHL affiliate, the Portland Pirates, but did got his first taste of NHL action during the 2010-11 season. In 8 games for the Sabres, he recorded a goal and added an assist.
On June 25, 2011, he and Chris Butler were traded to the Calgary Flames for Robyn Regehr, Ales Kotalik and a second round pick in the 2012 NHL Entry Draft.