Murph Chamberlain played senior hockey for the Frood Tigers in Sudbury before turning to professional hockey in 1937 as a member of the Toronto Maple Leafs. During that first NHL season, Chamberlain scored four goals and 16 points in 43 games. He followed that up in 1938-39 scoring ten goals and 26 points. He also surpassed the 20-point barrier in 1939-40, counting 22 points. In each of his seasons with the Leafs they advanced to the Stanley Cup finals, only to finish second on each occasion to Chicago, Boston and New York.
In 1940-41, Chamberlain signed with the Montreal Canadiens and scored ten goals and 25 points in 45 games. Midway through the following season, he was sent to the New York Americans where he finished out the last eleven games of the year.
In 1942-43, Chamberlain signed with the Boston Bruins. He had nine goals and 33 points as the team made it to the Stanley Cup finals where they lost in four-straight games to the Detroit Red Wings.
The Montreal Canadiens were looking for additional scoring in the fall of 1943, so Chamberlain rejoined them for a second tour of duty. That first year back in Montreal proved to be the most productive of his career, averaging a point per game, scoring 15 goals and 47 points in 47 games. To cap off a great regular season, Chamberlain was part of his first NHL championship team as the Canadiens went on to win the Stanley Cup, turning back Chicago in four straight games.
The Canadiens were unsuccessful in defending their title the following year, but they did re-group to win the Cup in 1946, dropping the Boston Bruins four-games-to-one. Chamberlain remained with the Habs for another three seasons, retiring after the 1948-49 campaign having appeared in 510 games, scoring 100 goals and 275 points in a 12-year NHL career. The only regret Chamberlain had relating to hockey was his decision to pursue coaching after his playing days had ended.