In his four years at Providence the Edmonton, Alberta native tallied 56 goals and 97 assists for 153 points in 147 games played.

Following a successful collegiate career, Pisani joined Edmonton's AHL affiliate in Hamilton for the 2000-01 season and finished his rookie campaign with 12 goals and 25 points before more than doubling his offensive totals in each category. Pisani went on to finish fourth in team scoring with 26 goals, 34 assists for 60 points, before making his NHL debut with the Oilers the following year.

In 2002-03, Pisani split his season with Hamilton and Edmonton where in 35 games with the parent club he registered 13 points, before playing his first full season with the Oilers in 2003-04.

After competing with Langnau of the Swiss National League, and Asiago of the Italian league, Pisani returned to the NHL for the 2005-06 season. The hometown hero enjoyed his highest offensive output at the time notching 37 points in 80 games with the Oilers that season. In the 2006 playoffs, Pisani led the Cinderella Oilers in goals with 14 as the club would come within one game of winning their sixth franchise Stanley Cup.

In July of 2006, the unrestricted free agent Pisani signed a 4-year deal with the Edmonton Oilers.

Pisani missed the first 26 games of the 2007-08 season after being diagnosed with ulcerative colitis. He'd go on to suit up in 56 games for the Oilers and for his efforts he received a nomination for the Bill Masterton Trophy which is given to the player who best exhibits perseverance and dedication to hockey.

Injuries continued to plague the Edmonton native the following two seasons, limiting Pisani to just 38 and 40 games respectively.

On August 18, 2010, as unrestricted free agent, Pisani signed a one-year deal with the Stanley Cup champions the Chicago Blackhawks.